| Generic Name:
Bupropion HCL
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| Drug Class:
Withdrawal Agents
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| Description |
Zyban(Bupropion) is used in combination with a stop-smoking program (e.g., support group, counseling) to help you quit smoking. Zyban(Bupropion) can decrease your nicotine withdrawal symptoms (e.g., irritability, anxiety, restlessness) and your urge to smoke. Quitting smoking decreases your risk of heart and lung disease, as well as cancer.
Zyban(Bupropion) belongs to a class of medications known as antidepressants. It is not known exactly how bupropion works to reduce smoking urges. It may work by restoring the balance of certain natural chemicals (neurotransmitters) in the brain.
OTHER USES: Zyban(Bupropion) may also be used to treat other mental/mood disorders such as depression and attention deficit hyperactivity disorder (ADHD). It is also used with other mood stabilizers to treat bipolar disorder.
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| Proper
Use |
Read the Medication Guide and Patient Information Leaflet available from your pharmacist before you start taking Zyban(Bupropion) and each time you get a refill. Consult your doctor or pharmacist if you have any questions.
Take Zyban(Bupropion) by mouth, usually twice daily with or without food. If stomach upset occurs, take with food. It is important to take your doses at least 8 hours apart or as directed by your doctor to decrease your risk of seizure.
You may have trouble sleeping when you start taking Zyban(Bupropion). Do not take your evening dose too close to bedtime.
Swallow Zyban(Bupropion) whole. Do not crush, chew, or break the tablets. Doing so can destroy the slow release of the drug and may increase your risk of side effects, including seizures.
Your dosage is based on your medical condition and response to therapy. Your dose may be slowly increased to limit side effects. Do not take more or less medication than prescribed. Do not take more than 150 milligrams in a single dose. Do not take more than 300 milligrams per day. Taking more than the recommended dose of Zyban(Bupropion) may increase your risk of having a seizure.
It is recommended that you do not try to quit smoking until you have been taking Zyban(Bupropion) for 1 week so that the drug can reach a high enough level in your blood. Set a date for quitting, and stop smoking sometime in the second week of taking Zyban(Bupropion).
If necessary, Zyban(Bupropion) may be combined with nicotine patches or gum to help you quit smoking. Ask your doctor for more information. The combination of nicotine and this medication may increase your blood pressure. Your doctor may need to monitor your blood pressure closely. Do not smoke at any time if using any nicotine products with this drug. Too much nicotine can cause serious side effects.
Use Zyban(Bupropion) regularly in order to get the most benefit from it. To help you remember, use it at the same times each day.
Tell your doctor if you are not able to stop smoking after 7 to 12 weeks on Zyban(Bupropion).
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| Side
Effects |
Dry mouth and trouble sleeping may occur as your body gets used to the drug. Dizziness, drowsiness, nausea, diarrhea, fatigue, constipation, blurred vision, increased sweating, strange taste in mouth, or stomach pain may also occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
Remember that your doctor has prescribed Zyban(Bupropion) because the benefit to you is greater than the risk of side effects. Many people using Zyban(Bupropion) do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur: chest pain, fainting, fast/pounding heartbeat, irregular heartbeat, mental/mood changes (e.g., anxiety, agitation, confusion), muscle aches, ringing in the ears, severe headache, uncontrolled movements (tremor), unusual weight loss or gain, increase in the amount of urine, more frequent urination.
Zyban(Bupropion) may rarely cause seizures. Seek immediate medical attention if you experience a seizure. If you have a seizure while taking bupropion, you should not take this drug again.
A very serious allergic reaction to Zyban(Bupropion) is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing.
An empty tablet shell may appear in your stool. This is harmless.
If you notice other effects not listed above, contact your doctor or pharmacist.
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| Precautions |
Before taking Zyban(Bupropion), tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
Zyban(Bupropion) should not be used if you have certain medical conditions. Before using Zyban(Bupropion), consult your doctor or pharmacist if you have or have had: seizures, eating disorders (e.g., bulimia, anorexia nervosa).
Zyban(Bupropion) should not be used if you are suddenly stopping regular use of sedatives (e.g., benzodiazepines such as lorazepam) or alcohol, which may increase your risk of seizures.
Before using Zyban(Bupropion), tell your doctor or pharmacist your medical history, especially of: alcohol/drug dependence, brain tumor, diabetes, head injury, heart disease (e.g., congestive heart failure, recent heart attack), high blood pressure, kidney problems, liver problems (e.g., cirrhosis), mental/mood disorders (e.g., bipolar disorder, thoughts of suicide).
Zyban(Bupropion) may make you dizzy, drowsy or cause blurred vision; use caution engaging in activities requiring alertness or clear vision such as driving or using machinery. Limit or avoid alcoholic beverages. Alcohol can increase your risk of dizziness or seizures.
Do not take Zyban(Bupropion) with any other product that contains bupropion (e.g., antidepressants) since large doses of bupropion are more likely to cause seizures.
Kidney function declines as you grow older. Zyban(Bupropion) is removed by the kidneys. Therefore, elderly people may be more sensitive to this drug and to side effects.
Zyban(Bupropion) should be used only when clearly needed during pregnancy. Behavioral therapy and stop-smoking education is preferred for pregnant women who desire to stop smoking. Discuss the risks and benefits with your doctor.
Zyban(Bupropion) passes into breast milk and may have undesirable effects on a nursing infant. Breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.
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| Drug
Interactions |
Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.
Zyban(Bupropion) should not be used with the following medications because very serious interactions may occur: certain x-ray dyes such as iomeprol, sibutramine, thioridazine.
If you are currently using any of these medications, tell your doctor or pharmacist before starting Zyban(Bupropion).
Avoid taking MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine) during treatment and for 2 weeks before and after treatment with this medication. In some cases a serious, possibly fatal, drug interaction may occur.
Before using Zyban(Bupropion), tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: amantadine, diabetes medications (e.g., glipizide, glyburide, insulin), HIV drugs (e.g., efavirenz, nelfinavir, ritonavir), levodopa, regular use of sedatives (e.g., benzodiazepines such as lorazepam), stimulants (e.g., amphetamine, cocaine, "ecstasy," ephedrine), warfarin.
Also tell your doctor if you are taking any drugs which are affected by certain liver enzymes such as antidepressants (e.g., desipramine, paroxetine, fluoxetine), antipsychotics (e.g., haloperidol), beta-blockers (e.g., metoprolol), antiarrhythmics (e.g., propafenone, flecainide), orphenadrine, thiotepa, cyclophosphamide, carbamazepine, phenobarbital, or phenytoin, among others.
Also report the use of drugs which might increase seizure risk (decrease seizure threshold) when combined with Zyban(Bupropion) such as corticosteroids (e.g., prednisone), isoniazid (INH), phenothiazines (e.g., chlorpromazine), theophylline, or tricyclic antidepressants (e.g., amitriptyline) among others. Consult your doctor or pharmacist for details
Large amounts of caffeine and other stimulants, such as those found in weight loss and cold/sinus medications, can increase the chance of seizures with this drug. Check all prescription and nonprescription/herbal product labels for caffeine and other stimulants (e.g., ephedra). Consult your doctor or pharmacist for more information.
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| Overdose |
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If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. Symptoms of overdose may include: seizures, severe confusion, hallucinations, rapid heart rate, and loss of consciousness.
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| Missed
Dose |
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If you miss a dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
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| Storage |
Store the US product at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture.
Store the Canadian product at room temperature between 59-77 degrees F (15-25 degreesC) away from light and moisture.
Bupropion tablets may have a strange odor. This is normal, and the medication is still safe to use. Do not store in the bathroom. Keep all medicines away from children and pets.
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| Disclaimer |
| The above
information is intended to supplement, not substitute
for, the expertise and judgment of your physician, pharmacist
or other healthcare professional. It should not be construed
to indicate that use of the drug is safe, appropriate,
or effective for you. Consult your healthcare professional
before using this drug. |
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